Targeting p53: A guardian gone rogue
The normal wild type p53 is the most powerful tumor suppressor. It can prevent cancer by instructing the repair of damaged DNA, or alternatively triggering cell destruction when the DNA is irreparable. But p53 may stray from the path nature assigned it. The p53 gene itself can be damaged and become mutant, not only losing its tumor suppressor abilities but sometimes gaining oncogenic activities, opening the gate to cancer.
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